Play a central role in the membrane complexes SAM and TOM. By tunnel-shaped structures they transpo

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Scientists at the University of Freiburg, Dr. Martin van der Laan has managed to gain fundamental new insights manolos into the structure of mitochondria. Mitochondria are the microscopic plants of the cell, the energy stored in food make available, enabling central manolos life events. This energy transformation takes place in filigree shaped invaginations of biological membranes inside the mitochondria. Defects in these fine membrane structures can lead to serious diseases manolos of the muscles and the central manolos nervous system. Certain molecular machinery in the inner membrane, which in 2011 discovered manolos the Freiburg team are not only responsible for building this internal structure, but also play an important role in the assembly of the outer envelope membrane of mitochondria, the scientists report in the prestigious journal Molecular Biology of the Cell.
The investigated machines manolos are critical to maintaining the characteristic architecture inside the mitochondria and thus given the name "Mitochondrial Inner Membrane Organizing System" (MINOS). In their latest study, the working group together with colleagues from Graz / Austria, Warsaw / Poland and Groningen / Netherlands now shown that the function of MINOS for the emergence of mitochondrial architecture goes far beyond the previously assumed extent. In a collaboration of the SFB 746 and Cluster of Excellence Centre for Biological Signalling Studies (BIOSK) found Dr. Maria Bohnert Lena-Sophie Wenz and Ralf Zerbes out how MINOS the different membrane systems of mitochondria together.
Play a central role in the membrane complexes SAM and TOM. By tunnel-shaped structures they transport proteins in the mitochondrion and then build it into the outer membrane. The study of the Freiburg researchers have now shown that the block Fcj1 of MINOS at this for the survival of cells essential process is directly involved, manolos a protein from the family of Mitofiline. The inactivation of Fcj1 blocked incorporating manolos proteins into the outer mitochondrial membrane. These results show how molecular control switching points between mitochondrial membranes assembly and function of the cellular power plants. manolos The new insights gained will help to better understand the basics of the architecture of mitochondria. In the future, it might help to unravel disease manolos mechanisms manolos and influence, which are associated with an altered fine structure of mitochondria.
Original publication: Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Muller JM, Oeljeklaus S, Perschil I Warscheid B Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N Becker T, Pfanner N, van der Laan M: "Role of MINOS in protein biogenesis of the mitochondrial outer membrane", in: Molecular Biology of the Cell, published online August 23, 2012. http://www.molbiolcell.org/content/early/2012/08/20/mbc.E12-04-0295
Caption: The protein complex MINOS has a key role in the construction of two membrane systems of mitochondria. Minos is necessary for the internal architecture of the membrane and support by forming bridges of membrane incorporation of proteins into the outer membrane with TOM and SAM.
Contact: PD Dr. Martin van der Laan, Institute of Biochemistry and Molecular Biology Collaborative Research Centre 746 Albert-Ludwigs-University manolos Freiburg Phone: 0761/203-5270 Email: martin.van.der.laan @ biochemie.uni-freiburg.de